This page explains how Endometrin (progesterone vaginal insert) is used in IVF treatment. All information is educational. Talk to your doctor about your specific protocol and any questions or concerns about your medications.
Overview
| Brand name | Endometrin |
|---|---|
| Generic name | progesterone vaginal insert |
| Category | Progesterone Support |
| How it is given | vaginal |
| Common dosages | 100 mg twice daily, 100 mg three times daily |
| Typical timing | Starts before or at embryo transfer and continues through early pregnancy, typically until 8 to 10 weeks |
What to expect: common side effects
Side effects vary from person to person. Many people experience only mild effects while others find them more significant. All of these experiences are valid. Report any severe or unexpected symptoms to your care team right away.
- Vaginal discharge (white or off-white residue from the insert)
- Vaginal irritation or spotting
- Bloating
- Mood changes
- Breast tenderness
- Fatigue
Storage instructions
Store at room temperature between 15C and 30C (59F to 86F). Do not refrigerate or freeze. Keep in the original packaging.
Traveling with Endometrin
Endometrin can be stored at room temperature and does not require refrigeration, making it very travel-friendly. Pack in a clean, secure bag. It is cleared through airport security as medical necessity with proper documentation.
Tips from the IVF community
These are practical suggestions shared by people who have been through IVF. They are not a substitute for your clinic's guidance.
- Insert Endometrin as high in the vaginal canal as comfortable using the supplied applicator
- Wearing a thin pantiliner manages the discharge that is common with vaginal progesterone
- Some clinics allow you to insert it at night before bed to reduce daytime discharge
- Endometrin may be used alone or alongside other progesterone forms depending on your clinic protocol
- If you notice unusual discharge, pain, or heavy bleeding, contact your clinic right away
- Many people feel self-conscious about this medication. You are not alone.
Track this medication with TrackMyIVF
Set dose reminders, log side effects, and share your medication timeline with your care team. TrackMyIVF keeps everything in one place so you never miss a dose.
Learn about TrackMyIVFFrequently Asked Questions
Why do I have white discharge when using Endometrin?
Endometrin inserts dissolve vaginally and leave a white or off-white residue that appears as discharge. This is completely normal and expected, not a sign of infection. A panty liner can help manage it. If you notice unusual odor, pain, or heavy bleeding, contact your clinic.
Is Endometrin as effective as progesterone in oil?
Research shows that vaginal progesterone (including Endometrin) is effective luteal phase support for IVF cycles. Some studies suggest PIO may provide slightly higher blood levels, but outcomes are comparable in most patients. Your clinic will recommend the best option for your specific situation.
Can I miss a dose of Endometrin?
If you miss a dose, contact your clinic for guidance. Progesterone support is important in the early weeks after transfer, so consistent use matters. Using TrackMyIVF reminders can help you remember each dose.
When will I stop taking Endometrin?
Most clinics continue progesterone supplementation until 8 to 10 weeks of pregnancy, at which point the placenta typically produces adequate progesterone. Your doctor will tell you when to taper and stop.
Medical disclaimer: This page provides general educational information only. It is not medical advice and should not replace guidance from your doctor, nurse, or reproductive endocrinologist. Every person's treatment is unique. Always consult your care team before making any decisions about your medications or treatment plan.
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About the author
Viv
BSc, Patient Advocate
Founder, TrackMyIVF
I built TrackMyIVF because I needed it during my own journey. Every feature comes from real experience.